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Beste lezer,
Niettegenstaande de moeilijke economische context heeft de Stichting voor Alzheimer Onderzoek toch een meer dan bevredigend jaar achter de rug.
De milde giften van onze donatoren blijven ongeveer op hetzelfde peil, waarvoor we hen allen natuurlijk van harte danken.
De inkomsten uit schenkingen ter gelegenheid van verjaardagen, jubileums of begrafenissen zijn sterk toegenomen. Wij danken dan ook alle families die ons langs deze weg hebben gesteund.
En 'last but not least' ook de legaten ten voordele van de Stichting voor Alzheimer Onderzoek worden elk jaar significanter.
Al deze vormen van steun aan de Stichting voor Alzheimer Onderzoek hebben ervoor gezorgd dat we dit jaar onze steun aan het wetenschappelijk onderzoek naar de ziekte van Alzheimer nog kunnen opdrijven.
Wij financieren dit jaar dan ook maar liefst 9 nieuwe onderzoeksprojecten voor een bedrag van 700.000 EUR. Daarnaast, en in samenwerking met de Koning Boudewijnstichting via het fonds 'Aline', kunnen we nog één extra project financieren, goed voor nog eens 100.000 EUR. Dit brengt onze totale financiële steun aan het onderzoek dit jaar op 800.000 EUR!
Wij zijn dan ook alle milde schenkers en de Koning Boudewijnstichting dankbaar voor hun vertrouwen in onze stichting en voor hun financiële steun aan het onderzoek.
Samen met jullie allen zullen wij blijven werken aan een toekomst zonder Alzheimer.
Meteen maak ik van de gelegenheid gebruik om u allen een vreugdevolle Kerst en een voorspoedig en gelukkig nieuwjaar toe te wensen.
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Wilfried Nys
Voorzitter SAO
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Awarded in 2010
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Follow-up of genome-wide association studies in a powerful study population of Belgian FTLD patients. VIB Department of Molecular Genetics, Neurodegenerative brain disease Group, University of Antwerp, Antwerpen
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Julie van der Zee 2011-2012 (10008)
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€ 50000
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Yeast-based models to study the Alzheimer's disease associated protein Pin1. Department of Biology, Laboratory for Functional Biology, Catholic University of Leuven, Leuven
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Vanessa Franssens
2011-2012 (10015)
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€ 50000
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Characterization of the risk effect of GRN missense mutations using a knock-in mouse model. VIB Department of Molecular Genetics, Neurodegenerative brain disease Group, University of Antwerp, Antwerpen
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Nathalie Brouwers
2011-2011 (10012)
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€ 25000
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Morphological and Molecular dissection of the γ-secretase independent function of Presenilins in trafficking. VIB Department of Molecular and Developmental Genetics, Laboratory for Membrane Trafficking, Catholic University of Leuven, Leuven
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Wim Annaert
2011-2012 (10010)
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€ 100000
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Transmembrane helix association in APP processing and gamma-secretase activity. Laboratory of Experimental Pharmacology, Catholic University of Louvain, Brussel
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Pascal Kienlen-Campard
2011-2012 (10016)
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€ 87000
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Camelid nanobodies as therapeutic to curb gelsolin amyloidosis. VIB Department Medical protein Research, Nanobody laboratory, Univerisyt of Ghent, Gent
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Jan Gettemans
2011-2012 (10005)
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€ 75496
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Identification of the chromosome 9p FTD-MND genetic defect using next generation genomics. VIB Department of Molecular Genetics, Neurodegenerative brain disease Group, University of Antwerp, Antwerpen
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Marc Cruts
2011-2012 (10014)
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€ 100000
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Biomarkers for differential dementia diagnosis. Institute Born-Bunge, Laboratory of Neurochemistry and Behavior, University of Antwerp, Antwerpen
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Sebastiaan Engelborghs
2011-2012 (10017)
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€ 100000
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Awarded in 2009
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Identification of a novel FTLD-TDP gene through molecular genomic analysis of a 9p-linked FTLD-TDP family. VIB Department of Molecular Genetics, Neurodegenerative brain disease Group, University of Antwerp, Antwerpen
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Ilse Gijselinck
2010-2011 (09016)
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€ 40000
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The substrate docking site of γ-Secretase: An alternative target in AD therapy? VIB Center for Human Genetics, Laboratory of Neuronal Cell Biology and Gene Transfer, Catholic University of Leuven, Leuven
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Lucía Chávez-Gutiérrez
2010-2011 (09017)
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€ 40000
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Characterization of a Grn knock-in mouse model to elucidate the effect of GRN missense mutations. VIB Department of Molecular Genetics, Neurodegenerative brain disease Group, University of Antwerp, Antwerpen
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Nathalie Brouwers
2010-2010 (09008)
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€ 20000
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Molecular correlations between Alzheimer's Disease and Fragile X Syndrome. VIB Center for Human Genetics, Laboratory for Molecular Neuroscience, Catholic University of Leuven, Leuven
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Claudia Bagni
2010-2011 (09020)
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€ 80000
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Molecular genetics of Lewy Body dementias. VIB Department of Molecular Genetics, Neurodegenerative brain disease Group, University of Antwerp, Antwerpen
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Jessie Theuns
2010-2011 (09007)
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€ 80000
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The effect of Abeta length on the progress to AD - stability of toxic intermediates. Department of Applied Biological Sciences VIB Switch Laboratory, Free University of Brussels, Brussel
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Kerensa Broersen
2010-2010 (09005)
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€ 40000
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A genome-wide exploration of structural variation in susceptibility to Alzheimer's disease. VIB Department of Molecular Genetics, Neurodegenerative brain disease Group, University of Antwerp, Antwerpen
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Kristel Sleegers
2010-2011 (09014)
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€ 80000
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Translational research into the role of progranulin in neurodegeneration. VIB Vesalius Research Center, Laboratory of Neurobiology, Catholic University of Leuven, Leuven
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Philip Van Damme
2010-2011 (09002)
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€ 80000
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Brain Aβ amyloidosis and the brain's response in cognitively intact elderly volunteers. Department of Neurosciences, Laboratory of Cognitive Neurology, Catholic University of Leuven, Leuven
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Rik Vandenberghe
2010-2010 (09013)
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€ 40000
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Awarded in 2008
Dr. Bart Dermaut 2008-2010 (08606) € 40 000
Drosophila as a model system to study tau and TDP-43 proteinopathies.
VIB Laboratory of Developmental Genetics, KUL, Leuven
Dr. Julie van der Zee 2008-2010 (08616) € 40 000
Biosampling and extended phenotyping of FTLD patients.
VIB Department of Molecular Genetics, Neurodegenerative brain disease Group,
University of Antwerp, Antwerpen
Dr. Nathalie Pierrot 2008-2009 (08610) € 20 000
Alteration of neuronal metabolism of cholesterol by APP.
Laboratory of Experimental Pharmacology, UCL, Brussel
Dr. Philip Van Damme 2008-2009 (08615) € 20 000
The role of progranulin in neurodegeneration.
VIB Vesalius Research Center, Laboratory of Neurobiology, KUL, Leuven
Prof. Dr. Eric Salmon 2008-2010 (08612) € 80 000
Neural basis of anosognosia in Alzheimer’s disease.
Cyclotron Research Center, ULg, Liège
Prof. Dr. Jean-Pierre Brion 2008-2010 (08604) € 80 000
Relationship between conditional tau expression and rescue of
mutant APP-induced phenotype in an animal model of Alzheimer’s disease.
Laboratory of General Histology, Neuroanatomy and Neuropathology,
ULB, Brussel
Prof. Dr. Marc Cruts 2008-2010 (08605) € 80 000
Search for genes affecting progranulin-mediated neurodegeneration
VIB Department of Molecular Genetics, Neurodegenerative brain disease Group,
University of Antwerp, Antwerpen
Prof. Dr. Sebastiaan Engelborghs 2008-2010 (08607) € 80 000
Validation of biomarkers for dementia and mild cognitive impairment.
Laboratory of Neurochemistry and Behavior, Institute Born-Bunge,
University of Antwerp, Antwerpen
Prof. Dr. Samir Kumar-Singh 2008-2010 (08608) € 80 000
Elucidating PGRN loss-of-function in neurodegeneration.
VIB Department of Molecular Genetics, Neurodegenerative brain disease Group,
University of Antwerp, Antwerpen
Prof. Dr. Willem Annaert 2008-2010 (08601) € 80 000
Localization and Targeting of distinct γ-secretase complexes.
VIB Department of Molecular and Developmental Genetics,
Laboratory for Membrane Trafficking, KUL, Leuven
Awarded in 2007
Prof. Dr Joost Schymkowitz 2007-2008 (07603) € 37 500
Structural study of A oligomers in Alzheimer’s disease.
VIB Switch laboratory, VUB, Brussel
Dr. Jessie Theuns 2007-2009 (07602) € 80 000
Molecular genetics of Lewy Body dementias.
VIB Department of Molecular Genetics, Neurodegenerative brain disease Group,
University of Antwerp, Antwerpen
Prof. Dr. Pascal Kienlen-Campard 2007-2009 (07604) € 80 000
Role of GxxxG motifs in APP dimerization and function.
Laboratory of Experimental Pharmacology, UCL, Brussel
Prof. Dr. Bart De Strooper 2008-2010 (08601) € 240 000
MicroRNA dysregulation in Alzheimer’s disease.
VIB Department of Molecular and Developmental Genetics,
Laboratory of Neuronal Cell Biology and Gene Transfer, KUL, Leuven
Awarded in 2006
Prof. Dr. Willem Annaert 2006-2008 (06605) € 80 000
Imaging the trafficking and processing of γ-secretase substrates.
VIB Department of Molecular and Developmental Genetics,
Laboratory for Membrane Trafficking, KUL, Leuven
Prof. Dr. Marc Cruts 2006-2008 (06606) € 80 000
Studies to identify the genetic defect causing FTDU-17.
VIB Department of Molecular Genetics, Neurodegenerative brain disease Group,
University of Antwerp, Antwerpen
Prof. Dr. Carlos Dotti 2006-2008 (06604) € 80 000
Identification in vivo of tau-phosphorylation regulators.
VIB Department of Molecular and Developmental Genetics,
Laboratory of Neuronal Differentiation, KUL, Leuven
Prof. Dr. Samir Kumar-Singh 2006-2008 (06607) € 80 000
Vessel-related chaperones in dense-core plaque formation.
VIB Department of Molecular Genetics, Neurodegenerative brain disease Group,
University of Antwerp, Antwerpen
Prof. Dr. Anton Roebroek 2006-2007 (06601) € 40 000
The dual role of LRP1 in generation and clearance of Aß.
VIB Experimental Mouse Genetics, KUL, Leuven
Prof. Dr. Jean-Noël Octave 2006-2007 (06608) € 40 000
Role of the membrane GxxxG motifs in APP processing.
Laboratory of Experimental Pharmacology, UCL, Brussel
Dr. Karelle Leroy 2006-2008 (06654) € 40 000
Effects of lithium and rapamycin on taupathology in a tau transgenic model.
Laboratory of Histology, Neuroanatomy and Neuropathology, ULB, Brussel
Dr. Kristel Sleegers 2006-2008 (06651) € 40 000
Molecular genetics of memory and Alzheimer’s disease.
VIB Department of Molecular Genetics, Neurodegenerative brain disease Group,
University of Antwerp, Antwerpen
Dr. Amantha Thathiah 2006-2008 (06653) € 40 000
In Vivo characterization of the alpha-secretase Involved in AD,
VIB Department of Molecular and Developmental Genetics,
Laboratory of Neuronal Cell Biology and Gene Transfer, KUL, Leuven
Dr. Debby Van Dam 2006-2008 (06652) € 40 000
Pathophysiological mechanisms in amyloidosis mouse models.
Laboratory of Neurochemistry and Behavior, Institute Born-Bunge,
University of Antwerp, Antwerpen
Awarded in 2005
Dr. Sebastiaan Engelborghs 2005-2007 (05603) € 78 000
Characterisation of biological markers of dementia.
Laboratory of Neurochemistry and Behavior, Institute Born-Bunge,
University of Antwerp, Antwerpen
Prof. Dr. Joris Winderickx 2005-2007 (05602) € 79 000
Hunanized yeast models to study Tau-aggregation.
Department of Biology, Laboratory of Functional Biology, KUL, Leuven
Prof. Dr. Bart De Strooper/ 2005-2006 (extension 04601) € 39 400
Dr. Karina Reiß
Analysis of BACE deficient mice.
VIB Department of Molecular and Developmental Genetics,
Laboratory of Neuronal Cell Biology and Gene Transfer, KUL, Leuven
Prof. Dr. Marc Cruts 2005-2006 (extension 04604) € 40 000
Molecular genetics of chr 17-linked tau negative dementia.
VIB Department of Molecular Genetics, Neurodegenerative brain disease Group,
University of Antwerp, Antwerpen
Prof. Dr. Anton Roebroek 2005-2006 (extension 04602) € 40 000
The role of LRP1 in -amyloid peptide metabolisme.
VIB Experimental Mouse Genetics, KUL, Leuven
Prof. Dr. Willem Annaert 2005-2006 (extension 04603) € 40 000
Regulation of γ-sectretase assembly in ER- Golgi transport.
VIB Department of Molecular and Developmental Genetics,
Laboratory for Membrane Trafficking, KUL, Leuven
Awarded in 2004
Dr. Diana Dominguez / 2004-2005 (04601) € 39 400
Dr. Karina Reiß
Analysis of BACE deficient mice.
VIB Department of Molecular and Developmental Genetics,
Laboratory of Neuronal Cell Biology and Gene Transfer, KUL, Leuven
Prof. Dr. Marc Cruts 2004-2005 (04604) € 40 000
Molecular genetics of chr 17-linked tau negative dementia.
VIB Department of Molecular Genetics, Neurodegenerative brain disease Group,
University of Antwerp, Antwerpen
Prof. Dr. Anton Roebroek 2004-2005 (04602) € 40 000
The role of LRP1 in ß-amyloid peptide metabolisme.
VIB Experimental Mouse Genetics, KUL, Leuven
Prof. Dr. Willem Annaert 2004-2005 (04603) € 40 000
Regulation of γ-sectretase assembly in ER- Golgi transport.
VIB Department of Molecular and Developmental Genetics,
Laboratory for Membrane Trafficking, KUL, Leuven
Awarded in 2003
Prof. Dr. Jean-Pierre Brion 2003-2005 (03601) € 80 000
Role of glycogen synthase kinase 3ß in tau phosphorylation in
and neurofibrillary tangles formation in Alzheimer’s disease.
Laboratory of General Histology, Neuroanatomy and Neuropathology, ULB, Brussel
Prof. Dr. Samir Kumar-Singh 2003-2005 (03602) € 80 000
Characterisation of a novel APPT714I mise model.
VIB Department of Molecular Genetics, Neurodegenerative brain disease Group,
University of Antwerp, Antwerpen
Prof. Dr. Jean-Jacques Martin 2003-2005 (03603) € 68 000
Brain Bank of the Institute Born-Bunge (formerly Born-Bunge foundation).
Laboratory of neuropathology and electron microscopy, Institute Born-Bunge,
University of Antwerp, Antwerpen
Awarded in 2002
Prof.Dr. Willem Annaert / 2002-2004 (02602) € 87 000
Prof.Judith Klumpermann
Subcellular localization of the active secretase complex.
VIB Department of Molecular and Developmental Genetics,
Laboratory for Membrane Trafficking, KUL, Leuven / University of Utrecht;
cross border project BE/NL
Prof. Dr. Christine Van Broeckhoven 2002-2004 (02601) € 87 000
Identification of novel genes for Alzheimer dementia and related disorders.
VIB Department of Molecular Genetics, Neurodegenerative brain disease Group,
University of Antwerp, Antwerpen
Prof. Dr. Fred van Leuven / 2002-2004 (02604-02506) € 37 000
Dr. Jan de Vente
Function and regulation of NO-cGMP signaling transduction in cholinergic neurons.
Experimental genetics Group, Campus Gasthuisberg, KUL,
Leuven /University of Maastricht; cross border project BE/NL
Awarded in 2001
Prof. Dr. Fred Van Leuven / 2001-2003 (01601-01504) € 136 341,33
Dr. David Fisher
Crossing Alzheimer mouse models.
Experimental genetics Group, Campus Gasthuisberg, KUL,
Leuven / IBNR cross border project BE/NL
Prof. Dr. Etienne Nouwen 2001-2002 (01600) € 37 184,02
Chromogranins and neuron-mocroglia interaction in Alzheimers disease.
Laboratory of Neuropharmacology, Department of Biomedical Sciences,
University of Antwerp, Antwerpen
Awarded in 2000
Prof. Dr. Christine Van Broeckhoven 2000-2001 € 49 578,70
Genetic and phenotypical analysis of Alzheimer’s disease.
VIB Department of Molecular Genetics, Neurodegenerative brain disease Group,
University of Antwerp, Antwerpen
Awarded in 1998
Prof. Dr. Christine Van Broeckhoven 1998-2000 (98603) € 86 762,73
Genetic and physical analysis of Alzheimer disease genes.
VIB Department of Molecular Genetics, Neurodegenerative brain disease Group,
University of Antwerp, Antwerpen
Dr. Diederik Moechars 1998-2000 (98602) € 86 394,71
Transgenic mouse and rat models for Alzheimer’s disease.
Experimental genetics Group, Faculty of Medicine, KUL, Leuven
Prof. Dr. Jean-Pierre Brion 1998-2000 (98608) € 86 281,17
Generation of neurofibrillary tangles in tau transgenic mice.
Laboratory of General Histology, Neuroanatomy and Neuropathology, ULB, Brussel
Dr. Chrisine Labeur 1998-2000 (98606) € 44 620,83
Lipoproteins and amyloid beta in Alzheimer’s disease.
Laboratory for Lipoprotein, Chemistry Unit, University of Ghent, Gent
Prof. Dr. Bart De Strooper 1998-2000 (98605) € 44 620,83
Modulating presenilin expression with lentiviral vectors.
Experimental genetics Group, Faculty of Medicine, KUL, Leuven
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Awarded in 2010
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Follow-up of genome-wide association studies in a powerful study population of Belgian FTLD patients. VIB Department of Molecular Genetics, Neurodegenerative brain disease Group, University of Antwerp, Antwerpen
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Julie van der Zee 2011-2012 (10008)
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€ 50000
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|
Yeast-based models to study the Alzheimer's disease associated protein Pin1. Department of Biology, Laboratory for Functional Biology, Catholic University of Leuven, Leuven
|
Vanessa Franssens
2011-2012 (10015)
|
€ 50000
|
|
Characterization of the risk effect of GRN missense mutations using a knock-in mouse model. VIB Department of Molecular Genetics, Neurodegenerative brain disease Group, University of Antwerp, Antwerpen
|
Nathalie Brouwers
2011-2011 (10012)
|
€ 25000
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|
Morphological and Molecular dissection of the γ-secretase independent function of Presenilins in trafficking. VIB Department of Molecular and Developmental Genetics, Laboratory for Membrane Trafficking, Catholic University of Leuven, Leuven
|
Wim Annaert
2011-2012 (10010)
|
€ 100000
|
|
Transmembrane helix association in APP processing and gamma-secretase activity. Laboratory of Experimental Pharmacology, Catholic University of Louvain, Brussel
|
Pascal Kienlen-Campard
2011-2012 (10016)
|
€ 87000
|
|
Camelid nanobodies as therapeutic to curb gelsolin amyloidosis. VIB Department Medical protein Research, Nanobody laboratory, Univerisyt of Ghent, Gent
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Jan Gettemans
2011-2012 (10005)
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€ 75496
|
|
Identification of the chromosome 9p FTD-MND genetic defect using next generation genomics. VIB Department of Molecular Genetics, Neurodegenerative brain disease Group, University of Antwerp, Antwerpen
|
Marc Cruts
2011-2012 (10014)
|
€ 100000
|
|
Biomarkers for differential dementia diagnosis. Institute Born-Bunge, Laboratory of Neurochemistry and Behavior, University of Antwerp, Antwerpen
|
Sebastiaan Engelborghs
2011-2012 (10017)
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€ 100000
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|
Awarded in 2009
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Identification of a novel FTLD-TDP gene through molecular genomic analysis of a 9p-linked FTLD-TDP family. VIB Department of Molecular Genetics, Neurodegenerative brain disease Group, University of Antwerp, Antwerpen
|
Ilse Gijselinck
2010-2011 (09016)
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€ 40000
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|
The substrate docking site of γ-Secretase: An alternative target in AD therapy? VIB Center for Human Genetics, Laboratory of Neuronal Cell Biology and Gene Transfer, Catholic University of Leuven, Leuven
|
Lucía Chávez-Gutiérrez
2010-2011 (09017)
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€ 40000
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Characterization of a Grn knock-in mouse model to elucidate the effect of GRN missense mutations. VIB Department of Molecular Genetics, Neurodegenerative brain disease Group, University of Antwerp, Antwerpen
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Nathalie Brouwers
2010-2010 (09008)
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€ 20000
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Molecular correlations between Alzheimer's Disease and Fragile X Syndrome. VIB Center for Human Genetics, Laboratory for Molecular Neuroscience, Catholic University of Leuven, Leuven
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Claudia Bagni
2010-2011 (09020)
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€ 80000
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Molecular genetics of Lewy Body dementias. VIB Department of Molecular Genetics, Neurodegenerative brain disease Group, University of Antwerp, Antwerpen
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Jessie Theuns
2010-2011 (09007)
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€ 80000
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|
The effect of Abeta length on the progress to AD - stability of toxic intermediates. Department of Applied Biological Sciences VIB Switch Laboratory, Free University of Brussels, Brussel
|
Kerensa Broersen
2010-2010 (09005)
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€ 40000
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|
A genome-wide exploration of structural variation in susceptibility to Alzheimer's disease. VIB Department of Molecular Genetics, Neurodegenerative brain disease Group, University of Antwerp, Antwerpen
|
Kristel Sleegers
2010-2011 (09014)
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€ 80000
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|
Translational research into the role of progranulin in neurodegeneration. VIB Vesalius Research Center, Laboratory of Neurobiology, Catholic University of Leuven, Leuven
|
Philip Van Damme
2010-2011 (09002)
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€ 80000
|
|
Brain Aβ amyloidosis and the brain's response in cognitively intact elderly volunteers. Department of Neurosciences, Laboratory of Cognitive Neurology, Catholic University of Leuven, Leuven
|
Rik Vandenberghe
2010-2010 (09013)
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€ 40000
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Awarded in 2008
Dr. Bart Dermaut 2008-2010 (08606) € 40 000
Drosophila as a model system to study tau and TDP-43 proteinopathies.
VIB Laboratory of Developmental Genetics, KUL, Leuven
Dr. Julie van der Zee 2008-2010 (08616) € 40 000
Biosampling and extended phenotyping of FTLD patients.
VIB Department of Molecular Genetics, Neurodegenerative brain disease Group,
University of Antwerp, Antwerpen
Dr. Nathalie Pierrot 2008-2009 (08610) € 20 000
Alteration of neuronal metabolism of cholesterol by APP.
Laboratory of Experimental Pharmacology, UCL, Brussel
Dr. Philip Van Damme 2008-2009 (08615) € 20 000
The role of progranulin in neurodegeneration.
VIB Vesalius Research Center, Laboratory of Neurobiology, KUL, Leuven
Prof. Dr. Eric Salmon 2008-2010 (08612) € 80 000
Neural basis of anosognosia in Alzheimer’s disease.
Cyclotron Research Center, ULg, Liège
Prof. Dr. Jean-Pierre Brion 2008-2010 (08604) € 80 000
Relationship between conditional tau expression and rescue of
mutant APP-induced phenotype in an animal model of Alzheimer’s disease.
Laboratory of General Histology, Neuroanatomy and Neuropathology,
ULB, Brussel
Prof. Dr. Marc Cruts 2008-2010 (08605) € 80 000
Search for genes affecting progranulin-mediated neurodegeneration
VIB Department of Molecular Genetics, Neurodegenerative brain disease Group,
University of Antwerp, Antwerpen
Prof. Dr. Sebastiaan Engelborghs 2008-2010 (08607) € 80 000
Validation of biomarkers for dementia and mild cognitive impairment.
Laboratory of Neurochemistry and Behavior, Institute Born-Bunge,
University of Antwerp, Antwerpen
Prof. Dr. Samir Kumar-Singh 2008-2010 (08608) € 80 000
Elucidating PGRN loss-of-function in neurodegeneration.
VIB Department of Molecular Genetics, Neurodegenerative brain disease Group,
University of Antwerp, Antwerpen
Prof. Dr. Willem Annaert 2008-2010 (08601) € 80 000
Localization and Targeting of distinct γ-secretase complexes.
VIB Department of Molecular and Developmental Genetics,
Laboratory for Membrane Trafficking, KUL, Leuven
Awarded in 2007
Prof. Dr Joost Schymkowitz 2007-2008 (07603) € 37 500
Structural study of A oligomers in Alzheimer’s disease.
VIB Switch laboratory, VUB, Brussel
Dr. Jessie Theuns 2007-2009 (07602) € 80 000
Molecular genetics of Lewy Body dementias.
VIB Department of Molecular Genetics, Neurodegenerative brain disease Group,
University of Antwerp, Antwerpen
Prof. Dr. Pascal Kienlen-Campard 2007-2009 (07604) € 80 000
Role of GxxxG motifs in APP dimerization and function.
Laboratory of Experimental Pharmacology, UCL, Brussel
Prof. Dr. Bart De Strooper 2008-2010 (08601) € 240 000
MicroRNA dysregulation in Alzheimer’s disease.
VIB Department of Molecular and Developmental Genetics,
Laboratory of Neuronal Cell Biology and Gene Transfer, KUL, Leuven
Awarded in 2006
Prof. Dr. Willem Annaert 2006-2008 (06605) € 80 000
Imaging the trafficking and processing of γ-secretase substrates.
VIB Department of Molecular and Developmental Genetics,
Laboratory for Membrane Trafficking, KUL, Leuven
Prof. Dr. Marc Cruts 2006-2008 (06606) € 80 000
Studies to identify the genetic defect causing FTDU-17.
VIB Department of Molecular Genetics, Neurodegenerative brain disease Group,
University of Antwerp, Antwerpen
Prof. Dr. Carlos Dotti 2006-2008 (06604) € 80 000
Identification in vivo of tau-phosphorylation regulators.
VIB Department of Molecular and Developmental Genetics,
Laboratory of Neuronal Differentiation, KUL, Leuven
Prof. Dr. Samir Kumar-Singh 2006-2008 (06607) € 80 000
Vessel-related chaperones in dense-core plaque formation.
VIB Department of Molecular Genetics, Neurodegenerative brain disease Group,
University of Antwerp, Antwerpen
Prof. Dr. Anton Roebroek 2006-2007 (06601) € 40 000
The dual role of LRP1 in generation and clearance of Aß.
VIB Experimental Mouse Genetics, KUL, Leuven
Prof. Dr. Jean-Noël Octave 2006-2007 (06608) € 40 000
Role of the membrane GxxxG motifs in APP processing.
Laboratory of Experimental Pharmacology, UCL, Brussel
Dr. Karelle Leroy 2006-2008 (06654) € 40 000
Effects of lithium and rapamycin on taupathology in a tau transgenic model.
Laboratory of Histology, Neuroanatomy and Neuropathology, ULB, Brussel
Dr. Kristel Sleegers 2006-2008 (06651) € 40 000
Molecular genetics of memory and Alzheimer’s disease.
VIB Department of Molecular Genetics, Neurodegenerative brain disease Group,
University of Antwerp, Antwerpen
Dr. Amantha Thathiah 2006-2008 (06653) € 40 000
In Vivo characterization of the alpha-secretase Involved in AD,
VIB Department of Molecular and Developmental Genetics,
Laboratory of Neuronal Cell Biology and Gene Transfer, KUL, Leuven
Dr. Debby Van Dam 2006-2008 (06652) € 40 000
Pathophysiological mechanisms in amyloidosis mouse models.
Laboratory of Neurochemistry and Behavior, Institute Born-Bunge,
University of Antwerp, Antwerpen
Awarded in 2005
Dr. Sebastiaan Engelborghs 2005-2007 (05603) € 78 000
Characterisation of biological markers of dementia.
Laboratory of Neurochemistry and Behavior, Institute Born-Bunge,
University of Antwerp, Antwerpen
Prof. Dr. Joris Winderickx 2005-2007 (05602) € 79 000
Hunanized yeast models to study Tau-aggregation.
Department of Biology, Laboratory of Functional Biology, KUL, Leuven
Prof. Dr. Bart De Strooper/ 2005-2006 (extension 04601) € 39 400
Dr. Karina Reiß
Analysis of BACE deficient mice.
VIB Department of Molecular and Developmental Genetics,
Laboratory of Neuronal Cell Biology and Gene Transfer, KUL, Leuven
Prof. Dr. Marc Cruts 2005-2006 (extension 04604) € 40 000
Molecular genetics of chr 17-linked tau negative dementia.
VIB Department of Molecular Genetics, Neurodegenerative brain disease Group,
University of Antwerp, Antwerpen
Prof. Dr. Anton Roebroek 2005-2006 (extension 04602) € 40 000
The role of LRP1 in -amyloid peptide metabolisme.
VIB Experimental Mouse Genetics, KUL, Leuven
Prof. Dr. Willem Annaert 2005-2006 (extension 04603) € 40 000
Regulation of γ-sectretase assembly in ER- Golgi transport.
VIB Department of Molecular and Developmental Genetics,
Laboratory for Membrane Trafficking, KUL, Leuven
Awarded in 2004
Dr. Diana Dominguez / 2004-2005 (04601) € 39 400
Dr. Karina Reiß
Analysis of BACE deficient mice.
VIB Department of Molecular and Developmental Genetics,
Laboratory of Neuronal Cell Biology and Gene Transfer, KUL, Leuven
Prof. Dr. Marc Cruts 2004-2005 (04604) € 40 000
Molecular genetics of chr 17-linked tau negative dementia.
VIB Department of Molecular Genetics, Neurodegenerative brain disease Group,
University of Antwerp, Antwerpen
Prof. Dr. Anton Roebroek 2004-2005 (04602) € 40 000
The role of LRP1 in ß-amyloid peptide metabolisme.
VIB Experimental Mouse Genetics, KUL, Leuven
Prof. Dr. Willem Annaert 2004-2005 (04603) € 40 000
Regulation of γ-sectretase assembly in ER- Golgi transport.
VIB Department of Molecular and Developmental Genetics,
Laboratory for Membrane Trafficking, KUL, Leuven
Awarded in 2003
Prof. Dr. Jean-Pierre Brion 2003-2005 (03601) € 80 000
Role of glycogen synthase kinase 3ß in tau phosphorylation in
and neurofibrillary tangles formation in Alzheimer’s disease.
Laboratory of General Histology, Neuroanatomy and Neuropathology, ULB, Brussel
Prof. Dr. Samir Kumar-Singh 2003-2005 (03602) € 80 000
Characterisation of a novel APPT714I mise model.
VIB Department of Molecular Genetics, Neurodegenerative brain disease Group,
University of Antwerp, Antwerpen
Prof. Dr. Jean-Jacques Martin 2003-2005 (03603) € 68 000
Brain Bank of the Institute Born-Bunge (formerly Born-Bunge foundation).
Laboratory of neuropathology and electron microscopy, Institute Born-Bunge,
University of Antwerp, Antwerpen
Awarded in 2002
Prof.Dr. Willem Annaert / 2002-2004 (02602) € 87 000
Prof.Judith Klumpermann
Subcellular localization of the active secretase complex.
VIB Department of Molecular and Developmental Genetics,
Laboratory for Membrane Trafficking, KUL, Leuven / University of Utrecht;
cross border project BE/NL
Prof. Dr. Christine Van Broeckhoven 2002-2004 (02601) € 87 000
Identification of novel genes for Alzheimer dementia and related disorders.
VIB Department of Molecular Genetics, Neurodegenerative brain disease Group,
University of Antwerp, Antwerpen
Prof. Dr. Fred van Leuven / 2002-2004 (02604-02506) € 37 000
Dr. Jan de Vente
Function and regulation of NO-cGMP signaling transduction in cholinergic neurons.
Experimental genetics Group, Campus Gasthuisberg, KUL,
Leuven /University of Maastricht; cross border project BE/NL
Awarded in 2001
Prof. Dr. Fred Van Leuven / 2001-2003 (01601-01504) € 136 341,33
Dr. David Fisher
Crossing Alzheimer mouse models.
Experimental genetics Group, Campus Gasthuisberg, KUL,
Leuven / IBNR cross border project BE/NL
Prof. Dr. Etienne Nouwen 2001-2002 (01600) € 37 184,02
Chromogranins and neuron-mocroglia interaction in Alzheimers disease.
Laboratory of Neuropharmacology, Department of Biomedical Sciences,
University of Antwerp, Antwerpen
Awarded in 2000
Prof. Dr. Christine Van Broeckhoven 2000-2001 € 49 578,70
Genetic and phenotypical analysis of Alzheimer’s disease.
VIB Department of Molecular Genetics, Neurodegenerative brain disease Group,
University of Antwerp, Antwerpen
Awarded in 1998
Prof. Dr. Christine Van Broeckhoven 1998-2000 (98603) € 86 762,73
Genetic and physical analysis of Alzheimer disease genes.
VIB Department of Molecular Genetics, Neurodegenerative brain disease Group,
University of Antwerp, Antwerpen
Dr. Diederik Moechars 1998-2000 (98602) € 86 394,71
Transgenic mouse and rat models for Alzheimer’s disease.
Experimental genetics Group, Faculty of Medicine, KUL, Leuven
Prof. Dr. Jean-Pierre Brion 1998-2000 (98608) € 86 281,17
Generation of neurofibrillary tangles in tau transgenic mice.
Laboratory of General Histology, Neuroanatomy and Neuropathology, ULB, Brussel
Dr. Chrisine Labeur 1998-2000 (98606) € 44 620,83
Lipoproteins and amyloid beta in Alzheimer’s disease.
Laboratory for Lipoprotein, Chemistry Unit, University of Ghent, Gent
Prof. Dr. Bart De Strooper 1998-2000 (98605) € 44 620,83
Modulating presenilin expression with lentiviral vectors.
Experimental genetics Group, Faculty of Medicine, KUL, Leuven
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Ons gratis nummer: 0800/90361
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